Dear Editor,

We’re interested in the article by Mo and colleagues[1] about“Evaluation of hyperreflective foci as a prognostic factor of visual outcome in retinal vein occlusion”. They performed a multiple linear regression analysis with backward elimination to analyse the association of best corrected visual acuity (BCVA) with the numbers of hyperre flective foci (HF)in different layers. In addition, they summarized the results of multivariate regression analyses in Table 3[1].

银行一年名义利率(X5)与寿险保费收入之间呈现显著的负相关，这说明当银行利率增加时，寿险购买者通常将寿险保单抵押或直接退保以取得现金向其他货币市场或资本市场投放,寿险需求下降;反之,在银行利率下降时,由于寿险公司对保单利率的调整具有迟延性,这时人们通常会积极投保,以此获得低价格高收益的保障,寿险需求上升。

本文以柔爆索爆炸加载为研究对象，通过发展理论模型，探索了在小装药比情况下内爆引起双层壳体碎片飞散的速度计算方法，得到以下结论：

However, it seems that Table 3[1] is not consisting of the results of a multiple regression analyses, rather, it is showing the results of Pearson correlation analysis. Surely, Pearson correlation analysis is already being done in multiple regression analyses automatically, but the main results of the regression analysis must have included the beta coefficients and related P values. And, Table 3[1] is lacking of those values.As it is already known, the multiple linear regression can be used not only to identify the association between two variables,but also help to forecast impacts of changes and predict trends.For instance, a multiple linear regression can tell you how much BCVA is expected to increase (or decrease) for every a number increase (or decrease) in HF.

We believe that, beta coefficients and related P values will also be crucial in understanding the exact association between BCVA and the numbers of HF in different layers.

ACKNOWLEDGEMENTS

1 Mo B, Zhou HY, Jiao X, Zhang F. Evaluation of hypereflective foci as a prognostic factor of visual outcome in retinal vein occlusion. Int JOphthalmol 2017;10(4):605-612.

Author Reply to the Editor

Conflicts of Interest: Bayat AH, None; Çakır A, None;Erden B, None; Bölükbaşı S, None; Şehirli ŞG, None.

REFERENCE

Dear Editor,

6）卫生部令第45号《可感染人类的高致病性病原微生物菌（毒）种或样本运输管理规定》（2006-02-01施行）。

私权观念和科学态度是知识产权战略的根本保障——纪念《国家知识产权战略纲要》颁布实施十年............................................................................................刘春田 06.03

Thanks for Dr. Alper Halil Bayat et al’s comments on our manuscript entitled “Evaluation of hyperreflective foci as a prognostic factor of visual outcome in retinal vein occlusion”.A little pity that Ididn’t put the beta coefficients and related P values in this paper, which may be confusing to the readers.Here is the table including the beta coefficients and related P values (Table 1).

Table 1 Results of multivariate regression on numbers of HF as a prognostic parameter for poor visual outcome

CRVO: Central retinal vein occlusion; BRVO: Branch retinal vein occlusion; ORL: Outer retinal layer; IRL: Inner retinal layer; RATIO:The ratio of HF numbers to the total areas of vitreous cavity.

Retinal layer 0.025 0.931 0.116 0.618 0.066 0.817 ORL -0.564 0.026 -0.675 0.000 -0.716 0.013 IRL 0.332 0.165 0.475 0.057 0.360 0.181 RATIO -0.482 0.052 -0.007 0.976 0.053 0.825

Bin Mo, Hai-Ying Zhou, Xuan Jiao, Feng Zhang

Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China